Chondrometrics was founded in and is rhondda escort agency at Freilassing, Germany, next to the Austrian border; it is a leading provider of medical image analysis for academia and industry. Using a regulatory compliant analysis pipeline, the company relies on MRI to offer quantitative imaging analysis of articular tissues and structural pathology, for research, epidemiological, and interventional studies, Its year experience in high rhondda escort agency image segmentation has recently been supplemented with fully automated image analysis approaches, using deep-learning AI technology. The ultimate goal is to qualify imaging endpoints as surrogate markers of clinical outcome in clinical trials, mainly for the regulatory approval of disease-modifying osteoarthritis drugs DMOADs. Where We Come From - Where We Are Chondrometrics GmbH has been founded by Felix Eckstein and Reinhard Putz, as a spin-off from the Ludwig-Maximilians Universität München Munich, Germany. Inthe company transitioned to Ainring, in the Southeast Germany, and in to its current location at Ludwig-Zeller-Str. What We Do Chondrometrics provides medical image analysis services to researchers in academia as well as in the medical device and pharmaceutical industry. The company relies on magnetic resonance imaging MRI to quantitatively analyze synovial joint structure and pathology, including but not limited to cartilage morphology and relaxometry e. The company maintains a GCP-compliant quality management system that is certified according to EN ISO link to certificate by medical device certification GmbH MDC and is regularly audited by MDC and other partners and clients. Chondrometrics recently started segmentation and analysis services using novel, fully automated technology using deep-learning AI approaches, specifically convolutional neural networks CNNs. In this area, the company profits from a rich resource of tissues segmentations generated over the years by its expert readers that can be used for training and validation of versatile and specific models for automated analysis in various contexts. These endpoint also help investigating male-female differences in articular tissue anatomy and pathology, helping to better understand and appreciate sex-differences in osteoarthritis in general. They can further elucidate resilience towards joint disease through unraveling functional adaptation processes of articular tissues. Imaging endpoints in epidemiological studies can identify risk factors of incidence and progression in osteoarthritis. This devastating degenerative joint disease causes structural changes in joint tissues, leading to pain, stiffness, and functional disability. Early diagnosis and careful clinical management are crucial to maintaining the patients' quality of life. With an aging population, the prevalence of osteoarthritis is bound to rise, stressing the need for effective and sustainable therapy. Apart from lifestyle changes and physiotherapy, current medical intervention is limited to managing pain. No medication is currently available to modify the structural pathology of articular tissues, disease-progression, and the natural history of osteoarthritis. Where We Are Heading The quantitative imaging measures developed and provided by Chondrometrics may be used in proof-of-concept POC trials of structural efficacy and safety. These may ensure that the intended mode-of-action MOA of a DMOAD targets the designated tissue, that the structural treatment effect is of sufficient magnitude to impact long-term clinical outcome, and that a potential sudden relieve in pain has no deleterious effect on the articular tissues. This type of alignment maximizes the chances of a clinical trial being successful, in that it provides clear and unambiguous answers as to whether an investigational medical product IMP has relevant impact on the structural pathology of joint tissues and on the natural progression of the disease osteoarthritis. Interested to learn more and here about the research done by company representatives. Please visit the RESEARCH Section on this page. Contact: eckstein chondrometrics. In Chondrometrics has continued to be heavily engaged in science. In keeping with our established year strategy, we have kept a strong focus on publication rather than business-only, an attitude certainly to be maintained throughout and beyond A great thank goes to our many outstanding collaborators. Given the collaborative approach of our research, they have been instrumental in generating the rhondda escort agency published below, which covers a wide range of imaging science: a image acquisition b image analysis including automated, DL-based approaches c imaging endpoints and biomarkers d imaging biomarker qualification e imaging application in interventional clinical trials RCTs f review articles on selected topics of imaging science The article covers are provided in the figure as well as a list of them, with the above topic categorizations, and links to abstract and full length articles, as far as available. We wish you all a good start of the New Year and a successful and productive ! The design of a sample rapid magnetic resonance imaging MRI acquisition rhondda escort agency supporting assessment of multiple articular tissues and pathologies in knee osteoarthritis. Eckstein F, Walter-Rittel TC, Chaudhari AS, Brisson NM, Maleitzke T, Duda GN, Wisser A, Wirth W, Winkler T. Osteoarthr Cartil Open. Clinical validation of fully automated laminar knee cartilage transverse relaxation time T2 analysis in anterior cruciate ligament ACL -injured knees- on behalf of the osteoarthritis OA -Bio consortium. Eckstein F, Brisson NM, Maschek S, Wisser A, Berenbaum F, Duda GN, Wirth W. Quant Imaging Med Surg. Evaluation of an automated laminar cartilage Rhondda escort agency relaxation time analysis method in an early osteoarthritis model. Wirth W, Maschek S, Wisser A, Eder J, Baumgartner CF, Chaudhari A, Berenbaum F, Eckstein F; OA-BIO Consortium. Skeletal Radiol. Is detection of disease-modifying osteoarthritis drug treatment more effective when performing cartilage morphometry without blinding to MR image acquisition order? Eckstein F, Wisser A, Maschek S, Wirth Rhondda escort agency, Ladel C, Bihlet AR, Knight C, Somberg K, Zhao L. Osteoarthritis Cartilage.
We have included a comprehensive set of secondary outcome criteria such as structural change, social adaptation, quality of social relationships, and therapeutic alliance to be used in such analyses. An independent group of statisticians without allegiance to either treatment provided randomization lists and did the final analyses. To test for a general trend in expected scores over time and for overall differences in the expected scores of the 4 treatment groups, a linear mixed model was fitted with the respective covariate included in addition to the baseline score, random intercept, and medication covariate and tested against the nested baseline model without the respective covariate. Until now, no RCT studies have compared long-term PAT and CBT directly. Mood regulation expectancies and emotion avoidance in depression vulnerability. During the meeting, all parties presented the work performed during the past 4 years, and it was nice to see things come together.
Evidenz aus randomisierten Studien
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